Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5078
Gene Symbol: PAX4
PAX4
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 ModifyingMutation RGD The R121W mutation in PAX4 is a predisposing factor for the development of type 2 diabetes in Okinawans. 12604352

2003
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 ModifyingMutation RGD Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. 17893236

2008
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.700 ModifyingMutation RGD Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta. 24239160

2014
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 ModifyingMutation RGD Meta-analysis of genome-wide gene expression differences in onset and maintenance phases of genetic hypertension. 20585107

2010
Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.600 ModifyingMutation RGD Insulin receptor is the target gene of miR-497, and elevated miR-497 might induce hepatic insulin resistance in HFD-MetS E3 Rats through inhibiting the expression of insulin receptor and confining the activation of IRS-1/PI3K/Akt/GSK-3β/GS pathway to insulin. 26300412

2015
Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0028754
Disease: Obesity
Obesity 		0.600 ModifyingMutation RGD Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition. 25612518

2015
Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 ModifyingMutation RGD Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis. 15241104

2004
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.550 ModifyingMutation RGD Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. 15888567

2005
Entrez Id: 1719
Gene Symbol: DHFR
DHFR
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.550 ModifyingMutation RGD Permissivity for methotrexate-induced DHFR gene amplification correlates with the metastatic potential of rat adenocarcinoma cells. 8149482

1994
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
CUI: C0036457
Disease: Scrapie
Scrapie 		0.550 ModifyingMutation RGD A novel vector for transgenesis in the rat CNS. 29157304

2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.540 ModifyingMutation RGD Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. 20428773

2010
Entrez Id: 7412
Gene Symbol: VCAM1
VCAM1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.540 ModifyingMutation RGD This region contains several physiological candidate genes for salt-sensitive hypertension in the SHRSP, including Edg1 and Vcam1, which are differentially expressed and lie on common and functionally important pathways. 17938382

2007
Entrez Id: 8797
Gene Symbol: TNFRSF10A
TNFRSF10A
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.520 ModifyingMutation RGD Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. 20428773

2010
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.520 ModifyingMutation RGD These data suggest that IL-1ra, released at sites of inflammation, limits inflammatory hyperalgesia. 10903985

2000
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.510 ModifyingMutation RGD Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy. 7771559

1995
Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 ModifyingMutation RGD Effects of STZ-induced diabetes and fasting on insulin receptor mRNA expression and insulin receptor gene transcription in rat liver. 1280238

1992
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 ModifyingMutation RGD Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats. 20695765

2011
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 ModifyingMutation RGD Paclitaxel alleviates liver fibrosis induced by bile duct ligation in rats: Role of TGF-β1, IL-10 and c-Myc. 30243650

2018
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0035078
Disease: Kidney Failure
Kidney Failure 		0.500 ModifyingMutation RGD Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin-1 receptor expression associated with its PPAR-γ agonist actions. 20888384

2011
Entrez Id: 4162
Gene Symbol: MCAM
MCAM
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma 		0.500 ModifyingMutation RGD There was no significant difference in both immunostainings for overexpression among the three histological subtypes of MM and the expression of CD146 and IMP3 was proportionally associated. 23621518

2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.500 ModifyingMutation RGD Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. 21416250

2011
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 ModifyingMutation RGD Dysregulation of BSEP and MRP2 May Play an Important Role in Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats and HepG2 Cells. 30068870

2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.400 ModifyingMutation RGD Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta. 24239160

2014
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0007112
Disease: Adenocarcinoma of prostate
Adenocarcinoma of prostate 		0.300 ModifyingMutation RGD Involvement of ERK1/2 in invasiveness and metastatic development of rat prostatic adenocarcinoma. 12688676

2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.300 ModifyingMutation RGD In well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, bcl-2 was expressed in some cells of tumour islands. 16309543

2005